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Published on: January 22, 2017
[Metabolic aspects of parsalmide in the cat (author's transl)]
Abstract:
2-Proparglyoxy-5-amino-N-(n-butyl)-benzamide(parsalmide, My 41-6) given s.c. to the cat and excreted in the urine, was present partly as unchanged parsalmide (25-62% of total excreted compounds), partly as unstably conjugated compounds (17-36%, mainly N-glucuronilparsalmide), and partly as stably conjugated compounds (11-36%, mainly N-acetylparsalmide). Urinary excretion of parsalmide and its metabolites continued for some days, indicating a slow excretion from the body, contrasting with other species, man included, previously examined. Summarizing, there are some 5-6 metabolites of parsalmide in the urine of treated cats, apart from unchanged parsalmide.
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