Arachnoidal cell hyperplasia. Its relationship to aging and chronic renal failure

The biological implications of human arachnoidal cell hyperplasia are unclear. In a study based on 922 autopsies performed over a four-year period that investigated the conditions associated with arachnoidal cell hyperplasia, hyperplasia was found in 184 cases (study cases). The incidence of arachnoidal cell hyperplasia was found to increase linearly with advancing age. In a case-control design used to ascertain any other clinical associations, 22 of the study cases had comcomitant chronic renal failure, whereas only four in a control group matched for age at time of death had chronic renal failure. No other associations were observed. Arachnoidal cell hyperplasia seems to be an age-related phenomenon and shows a statistically significant association with chronic renal failure.