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Induction of Experimental Autoimmune Hypophysitis in SJL Mice
Published on: December 17, 2010
Resistance to tolerance induction and age-dependent cellular changes in SJL mice
International Archives of Allergy and Applied Immunology
|January 1, 1977
Summary
Mice develop resistance to immune tolerance induction in early life. This resistance is linked to changes in T cells, not accessory cells, and is more pronounced in thymectomized recipients.
Area of Science:
- Immunology
- Developmental Biology
Background:
- Immune tolerance is crucial for preventing autoimmunity.
- Understanding the developmental window for tolerance induction is key.
Purpose of the Study:
- To investigate the age-dependent development of resistance to immune tolerance induction in SJL mice.
- To elucidate the role of accessory cells and T cell populations in this process.
Main Methods:
- Age-based analysis of tolerance induction in SJL mice.
- Assessment of radioresistant accessory cell function across different donor ages.
- Evaluation of tolerance induction in thymectomized recipients reconstituted with spleen cells.
Main Results:
- SJL mice acquire resistance to tolerance induction between 2 and 6 weeks of age.
- The age of accessory cell donors (3 vs. 12 weeks) does not influence tolerance induction.
- Thymectomized recipients reconstituted with adult spleen cells exhibit enhanced resistance to tolerance compared to intact animals.
Conclusions:
- Resistance to tolerance induction is primarily mediated by changes within T cells, not accessory cells.
- The rate of resistance development differs between thymus and spleen T cells.
- Altered proportions of T cell subpopulations may underlie age-dependent tolerance resistance.
