[Molsidomine in ergometric tests (author's transl)]

The effect of 2 mg sublingual molsidomine was evaluated in a double-blind cross-over study and compared to placebo in 9 patients with stable angina pectoris and ST-lowering of greater than or equal to 1 mm in the exercise ECG. Assessment of exercise tolerance (Watt-minute product) and ST-lowering during exercise with the bicycle ergometer was correlated with simultaneously measured blood plasma levels. An increase of maximal Watt-minute product from mean = 308.3 (s mean - 45.4) to mean = 74.4 (s mean = 138.7) was found after 1 hour with effectiveness over 5 hours. ST-lowering while on molsidomine was decreased from mean = 2.5 mm (s mean = 0.3) to a minimum of mean = 0.7 mm (s mean = 0.28) during identical work load. Action on the ST segment lasted for 3 hours. Blood plasma levels of molsidomine correlated to the drug action with a maximum after one hour and a half life of 2.03 hours.