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Thyroid-stimulating immunoglobulins in neonatal Graves's disease
Archives of Disease in Childhood
|November 1, 1980
Summary
Neonatal Graves' disease can be caused by maternal thyroid-stimulating immunoglobulins (TSAb) transferred during pregnancy. These antibodies were detected in affected infants and their mothers, disappearing in the babies by one year of age.
Area of Science:
- Endocrinology
- Immunology
- Neonatal Medicine
Background:
- Neonatal Graves' disease is a rare but serious condition affecting newborns.
- Maternal thyroid-stimulating immunoglobulins (TSAb) are implicated in the pathogenesis of Graves' disease.
Observation:
- This report details two cases of neonatal Graves' disease.
- One patient exhibited a delayed onset due to maternal antithyroid drug use suppressing fetal thyroid function.
- Thyroid-stimulating immunoglobulins (TSAb) were present in both affected infants and their mothers during the thyrotoxic phase.
Findings:
- TSAb were measurable in the neonates when thyrotoxic and in their mothers.
- TSAb became undetectable in the infants one year after birth.
- The presence and subsequent disappearance of TSAb strongly support their role in neonatal Graves' disease.
Implications:
- This study reinforces the significance of transplacental transfer of maternal TSAb in neonatal Graves' disease.
- Understanding TSAb dynamics is crucial for managing neonatal hyperthyroidism.
- Monitoring TSAb levels may aid in predicting and managing this condition.
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