[Effect of genotype on the angiotensin-forming system of plasma and the hypothalamus]

It is shown that hypothalamic renin-like enzyme of mice (lines C57B1/6 and BALB/c) consists of two forms differing from one another in their molecular weight. The allele AY determines the absence of the heavy form of renin-like hypothalamic enzyme (RLHE) and a relatively low level of activity of the blood plasma renin in intact animals. The heavy form of RLHE disappears in mice in case of a considerable dehydration.