Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Exophthalmos in autoimmune thyroid disease.

N Amino, T Yuasa, Y Yabu

The Journal of Clinical Endocrinology and Metabolism

|December 1, 1980

Summary

Patients with Graves' disease exhibit significantly increased eye protrusion compared to healthy individuals. This finding suggests Graves' ophthalmopathy may not be a distinct autoimmune condition, despite common exophthalmos.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Congenital hypothyroidism caused by a mutation in the Na+/I- symporter.

Nature genetics·1997

Same author

[Intra-individual and seasonal variations of thyroid function tests in healthy subjects].

Rinsho byori. The Japanese journal of clinical pathology·1996

Same author

Loss of biological activity of human chorionic gonadotropin (hCG) by the amino acid substitution on the "CMGCC" region of the alpha-subunit.

Molecular and cellular endocrinology·1994

Same author

[The background of the "Certification System for Certified Clinical Laboratory Physicians" and "Curriculum for Postgraduate Training in Clinical Pathology/Laboratory Medicine"].

Rinsho byori. The Japanese journal of clinical pathology·1994

Same author

[Molecular genetics of congenital isolated thyrotropin deficiency].

Nihon rinsho. Japanese journal of clinical medicine·1994

Same author

Ionizing radiation and autoimmunity. Induction of autoimmune disease in mice by high dose fractionated total lymphoid irradiation and its prevention by inoculating normal T cells.

Journal of immunology (Baltimore, Md. : 1950)·1994

Area of Science:

Endocrinology
Ophthalmology
Immunology

Background:

Autoimmune thyroid diseases, including Graves' disease and Hashimoto's disease, can affect the eyes.
Eye protrusion (exophthalmos) is a notable symptom in some patients with these conditions.
Understanding the prevalence and degree of exophthalmos is crucial for patient management.

Purpose of the Study:

To compare the degree of eye protrusion in patients with autoimmune thyroid diseases and healthy individuals.
To investigate the relationship between Graves' disease and exophthalmos.
To evaluate whether Graves' ophthalmopathy represents a distinct autoimmune entity.

Main Methods:

Quantitative measurement of eye protrusion using a standard method.
Comparison of mean protrusion values between patient groups (Graves' disease, Hashimoto's disease) and a control group of healthy subjects.
Statistical analysis to determine the significance of observed differences.

Main Results:

Patients with thyrotoxic Graves' disease showed significantly greater mean eye protrusion (16.6 mm) compared to healthy subjects (13.9 mm; P < 0.001).
Patients with Hashimoto's disease had slightly elevated mean eye protrusion (14.2 mm), but this was not significantly different from healthy subjects.
Individual protrusion values in Graves' disease were generally higher, indicating a widespread tendency towards exophthalmos.

Conclusions:

The study suggests that exophthalmos is a common characteristic in Graves' disease, affecting nearly all patients.
The findings challenge the concept of Graves' ophthalmopathy as a separate autoimmune disease.
Eye protrusion measurements can aid in understanding the spectrum of autoimmune thyroid disease manifestations.

Related Experiment Videos