Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does basic aluminum sucrose sulfate affect blood coagulability?

B F Mcgraw, E J Hesterlee, S L Gitomer

    Research Communications in Chemical Pathology and Pharmacology
    |November 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Commentary on the challenges of establishing gene medicines as a new class of therapeutics.

    Journal of drug targeting·2000
    Same author

    Beef allergy and the Persian Gulf syndrome.

    Medical hypotheses·1995
    Same author

    Interstitial cystitis and silk allergy.

    Medical hypotheses·1994
    Same author

    Intestinal absorption of dietary fat in patients with multiple sclerosis.

    Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)·1993
    Same author

    Isolation of a stable clone of the ameboid-adherent (AA) variant of Trichomonas vaginalis.

    The Journal of parasitology·1987
    Same author

    Vitamin B12 requirement for the growth of Trichomonas vaginalis in vitro.

    The Journal of parasitology·1985
    Same journal

    Is heat acclimation able to increase whole-body sensitivity to insulin?

    Research communications in chemical pathology and pharmacology·1994
    Same journal

    Vasodilator effects of clonidine on the mesenteric arterial beds in normotensive and spontaneously hypertensive rats.

    Research communications in chemical pathology and pharmacology·1994
    Same journal

    Elevation of ceruloplasmin activity involved in changes of hepatic metal concentration in primary biliary cirrhosis.

    Research communications in chemical pathology and pharmacology·1994
    Same journal

    Copper cytotoxicity impairs DNA synthesis but not protein phosphorylation upon growth stimulation in LEC mutant rat.

    Research communications in chemical pathology and pharmacology·1994
    Same journal

    Enhanced sensitivity of mdx mice to intramuscular injection of compound 48/80.

    Research communications in chemical pathology and pharmacology·1994
    Same journal

    Inhibition of antigen-induced airway hyperresponsiveness in rats: effects of ozagrel (a thromboxane A2 synthase inhibitor) and of CV-3988 (a platelet activating factor antagonist).

    Research communications in chemical pathology and pharmacology·1994
    See all related articles

    Sucralfate, a medication for duodenal ulcers, was evaluated for blood thinning effects. Studies confirmed sucralfate does not exhibit anticoagulant activity in patients undergoing treatment.

    Area of Science:

    • Pharmacology
    • Gastroenterology
    • Hematology

    Background:

    • Sucralfate is a basic aluminum sucrose sulfate compound.
    • Structurally similar to heparin, it lacks in vitro anticoagulant properties.
    • Previous research indicated no anticoagulant effects in animal models.

    Purpose of the Study:

    • To evaluate the potential anticoagulant effects of sucralfate in humans.
    • To assess sucralfate's safety profile regarding hemostasis.
    • To complement efficacy studies for duodenal ulcer disease.

    Main Methods:

    • Twenty-eight patients with duodenal ulcer disease were randomized to receive sucralfate.
    • Prothrombin time (PT) and activated partial thromboplastin time (aPTT) were measured.
    • Coagulation parameters were assessed before and after 2-4 weeks of sucralfate treatment.

    Related Experiment Videos

    Main Results:

    • No statistically significant changes in prothrombin time were observed.
    • No statistically significant changes in activated partial thromboplastin time were observed.
    • Sucralfate administration did not induce anticoagulant activity in patients.

    Conclusions:

    • Sucralfate does not possess clinically relevant anticoagulant effects.
    • The drug is safe for use in patients with duodenal ulcer disease concerning coagulation.
    • Sucralfate can be safely co-administered without interfering with normal hemostasis.