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Adrenal function and ascorbic acid concentrations in elderly women.

B Dubin, W J MacLennan, J C Hamilton

    Gerontology
    |January 1, 1978
    PubMed
    Summary
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    Low leucocyte ascorbic acid (LAA) levels in elderly women do not indicate adrenal insufficiency. Ascorbic acid supplementation did not alter cortisol responses to tetracosactrin (Synacthen) stimulation in this population.

    Area of Science:

    • Endocrinology
    • Geriatrics
    • Nutritional Science

    Background:

    • Elderly individuals often exhibit low leucocyte ascorbic acid (LAA) levels.
    • The clinical significance of low LAA in the elderly, particularly concerning adrenal function, remains unclear.

    Purpose of the Study:

    • To investigate whether low LAA levels in elderly women are associated with adrenal insufficiency.
    • To determine the effect of ascorbic acid supplementation on adrenal response to tetracosactrin (Synacthen) stimulation in this demographic.

    Main Methods:

    • Tetracosactrin (Synacthen) stimulation tests were conducted on 19 elderly women with LAA levels below 15 microgram/108 WBC.
    • Nine participants received oral ascorbic acid (200 mg/day) for two weeks; ten served as a control group.
    • Adrenal response, measured by plasma cortisol levels, was reassessed post-intervention.

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    Main Results:

    • Initial tetracosactrin tests showed all participants had normal plasma cortisol responses.
    • Ascorbic acid supplementation did not significantly alter the cortisol response to tetracosactrin stimulation in the treated group.
    • No significant differences in adrenal response were observed between the supplemented and untreated groups.

    Conclusions:

    • Low LAA levels in elderly women do not appear to be indicative of adrenal insufficiency.
    • Ascorbic acid supplementation does not correct or influence the normal adrenal response to tetracosactrin in this population.
    • These findings suggest that reduced LAA levels in the elderly do not compromise adrenal function.