[Effect of pirenzepine and atropine on the transmural gastric mucosal potential difference (author's transl)]

The transmural gastric mucosal potential difference (PD) measured by endoscopy has proved to be a good parameter in evaluating dose dependent effects of drugs. In 43 volunteers the maximum increases of the PD taken from the gastric juice were found after 30 mg pirenzepine and 0,5 and I mg atropin within 16 minutes. There was a significant difference between 20 and 30 mg pirenzepin. The dose of 20 mg pirenzepin seems to be insufficient to induce a maximum increase of PD in each individual.