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Related Experiment Videos

Changes in bile flow and composition induced by radiographic contrast materials.

J L Barnhart, R N Berk, B Combes

    Investigative Radiology
    |November 1, 1980
    PubMed
    Summary

    Radiographic contrast agents significantly alter bile composition and flow. Different chemical classes, like triiodophenyl alkanoates and triiodobenzoic acid dimers, induce varying choleretic responses, impacting bile volume and electrolyte content.

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    Area of Science:

    • Hepatology
    • Biliary Physiology
    • Pharmacology

    Background:

    • Hepatic excretion of radiographic contrast materials influences bile composition and volume.
    • The choleretic response to contrast agents varies widely based on their chemical structure and biliary excretion rates.

    Purpose of the Study:

    • To investigate the choleretic effects and bile composition changes induced by different classes of radiographic contrast materials.
    • To compare the choleretic response of iodoxamate (a triiodobenzoic acid dimer) with taurocholate and other choleretic agents.

    Main Methods:

    • Comparison of bile flow and composition changes following administration of iopanoic acid, RCK-136, iodoxamate, and taurocholate.
    • Analysis of electrolyte concentrations, particularly bicarbonate, in contrast agent-induced bile increments.

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  • Evaluation of iodoxamate-induced choleresis against other agents like diethyl maleate, DBcAMP, SC2644, and secretin.

    • Main Results:

    • RCK-136 (triiodophenyl alkanoate) is a potent choleretic, while iopanoic acid is not.
    • Triiodobenzoic acid dimers, like iodoxamate, increase bile flow within a narrow range.
    • Iodoxamate-induced bile flow showed a significantly higher bicarbonate concentration (52.3 mEq/l) compared to taurocholate-induced bile flow (25.3 mEq/l).
    • SC2644 also stimulated canalicular bile flow with high bicarbonate, similar to iodoxamate.

    Conclusions:

    • Radiographic contrast materials exert diverse effects on bile flow and composition.
    • Iodoxamate stimulates canalicular bile flow with a high bicarbonate concentration, suggesting a specific transport mechanism.
    • The choleretic effects of contrast agents are chemically dependent and can mimic or differ from endogenous bile acids.