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Poly (delta-L-ornithine).

K B Mathur, R K Pandey, M V Jagannadham

    International Journal of Peptide and Protein Research
    |February 1, 1981
    PubMed
    Summary
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    Researchers synthesized poly(delta-L-Orn), an iso-polypeptide using ornithine's delta-amino groups. Circular dichroism suggests this polymer may form a beta-pleated sheet conformation in solution.

    Area of Science:

    • Polymer Chemistry
    • Biochemistry
    • Structural Biology

    Background:

    • Polypeptides are typically formed using alpha-amino and alpha-carboxyl groups.
    • Iso-polypeptides utilize alternative functional groups for polymerization, leading to unique structures and properties.
    • Ornithine, an amino acid, possesses both alpha-amino and delta-amino groups, offering potential for iso-polypeptide synthesis.

    Purpose of the Study:

    • To describe a novel procedure for synthesizing poly(delta-L-Orn), an iso-polypeptide.
    • To investigate the secondary structure and conformational preferences of poly(delta-L-Orn) in solution.
    • To explore the potential of iso-polypeptides in adopting specific higher-order structures.

    Main Methods:

    • Synthesis of poly(delta-L-Orn) utilizing the delta-amino and alpha-carboxyl groups of ornithine.

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  • Preparation of a N-alpha-Boc protected derivative of poly(delta-L-Orn).
  • Circular dichroism spectroscopy to analyze the conformational properties of the synthesized polymers.

    • Main Results:

    • A viable synthetic route for poly(delta-L-Orn) was established.
    • Circular dichroism spectra indicated that poly(delta-L-Orn) and its N-alpha-Boc derivative may adopt a beta-pleated sheet-like conformation.
    • The study provides evidence for the structural potential of iso-polypeptides.

    Conclusions:

    • Poly(delta-L-Orn) can be synthesized by leveraging the delta-amino group of ornithine.
    • The beta-pleated sheet conformation is a plausible secondary structure for poly(delta-L-Orn) in solution.
    • This work expands the understanding of iso-polypeptide structures and their potential applications.