[Platelet dysfunction in diffuse toxic goiter and experimental thyrotoxicosis]

It was shown that in patients suffering from diffuse toxic goitre and in animals with experimental thyroxin toxicosis the platelet aggregation is decreased. Prostaglandin F2 alpha and cGMP restored platelet aggregating ability of patients and experimental animals while cAMP sharply lowered ADP-induced platelet aggregation in patients and animals with thyroxin toxicosis. Acetylsalicylic acid and indomethacin inhibited ADP-induced platelet aggregation approximately equally in patients and in healthy subjects. Thyroxin produced no effect on platelet aggregation in animals previously injected with indomethacin. It was concluded that disturbance of platelet aggregation in patients with diffuse toxic goitre proceeds like thrombopathy A.