Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methsuximide for refractory complex partial seizures.

B J Wilder, R A Buchanan

    Neurology
    |June 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Altered synaptic glutamate homeostasis contributes to cognitive decline in young APP/PSEN1 mice.

    Neurobiology of disease·2021
    Same author

    Short-term metabolic change is associated with improvement in measures of diabetic neuropathy: a 1-year placebo cohort analysis.

    Diabetic medicine : a journal of the British Diabetic Association·2010
    Same author

    Reliability and validity of the modified Toronto Clinical Neuropathy Score in diabetic sensorimotor polyneuropathy.

    Diabetic medicine : a journal of the British Diabetic Association·2009
    Same author

    Prenatal exposure to cigarette smoke affects the physiology of pedunculopontine nucleus (PPN) neurons in development.

    Neurotoxicology and teratology·2006
    Same author

    The electrochemical evaluation of a Zr-based bulk metallic glass in a phosphate-buffered saline electrolyte.

    Journal of biomedical materials research. Part A·2005
    Same author

    Effectiveness of vagus nerve stimulation in epilepsy patients: a 12-year observation.

    Neurology·2004
    Same journal

    Teaching Video NeuroImage: Tardive Blepharoclonus.

    Neurology·2026
    Same journal

    Teaching NeuroImage: Latent Axonal Degeneration in Patient With Anterior Circulation Stroke.

    Neurology·2026
    Same journal

    Incidental DWI-Positive Lesions in 2 Cohorts of CAA and CADASIL: Prevalence, Distribution, and Associations With Clinical Variables.

    Neurology·2026
    Same journal

    Alpha-Synuclein Seed Amplification Assay in CSF, Skin, and Submandibular Gland From Incidental Lewy Body Disease and Parkinson Disease.

    Neurology·2026
    Same journal

    Digital Semiology.

    Neurology·2026
    Same journal

    Early Cerebral Edema Subtypes and Functional Outcome in Patients With Cerebral Venous Thrombosis: Insights From the CLOT-VENUS Registry.

    Neurology·2026
    See all related articles

    Methsuximide effectively reduced complex partial seizures in patients refractory to other anticonvulsants. This adjunct medication achieved significant seizure control with manageable side effects in most participants.

    Area of Science:

    • Neurology
    • Clinical Pharmacology

    Background:

    • Complex partial seizures (psychomotor seizures) are challenging to manage with conventional anticonvulsants.
    • Patients with refractory epilepsy often require adjunctive therapies for optimal seizure control.

    Purpose of the Study:

    • To evaluate the efficacy and safety of methsuximide as an add-on therapy for complex partial seizures.
    • To determine optimal dosing and therapeutic plasma levels for methsuximide in this patient population.

    Main Methods:

    • A 12-week open-label study involving 21 patients with refractory complex partial seizures.
    • Methsuximide was added to existing anticonvulsant regimens.
    • Seizure frequency, treatment outcomes, and adverse events were monitored.

    Main Results:

    Related Experiment Videos

    • A significant reduction in weekly complex partial seizures from 5.8 to 0.9 per patient.
    • 71% of patients achieved 90-100% seizure control.
    • 42% of patients allowed for dose reduction or discontinuation of prior medications.
    • Optimal seizure control was associated with methsuximide doses of 9.5-11.0 mg/kg/day and plasma levels of 20-24 µg/mL.
    • Somnolence and lethargy were the most common adverse experiences, reported by 12 patients.

    Conclusions:

    • Methsuximide is an effective adjunct medication for managing complex partial seizures in patients refractory to conventional treatments.
    • The drug was generally well-tolerated, with adverse effects being manageable.
    • Therapeutic monitoring of methsuximide dosage and plasma levels is recommended for optimal outcomes.