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Updated: Jul 21, 2026

Aip1p Dynamics Are Altered by the R256H Mutation in Actin
Published on: July 30, 2014
Cell beta-actinin, an accelerator of actin polymerization, isolated from rat kidney cytosol
Abstract:
A motility-regulatory protein called cell beta-actinin was isolated from rat kidney cytosol. Although its molecular weight (approximately 80,000) is different from that of beta-actinin from skeletal muscle (heterodimer of 34,000 and 37,000), the action on actin is the same for both. Cell beta-actinin accelerates polymerization of actin by enhanced nucleation resulting in shorter actin filaments, inhibits the reassociation of sonicated F-actin fragments, and forms a Mg polymer in the presence of Mg ions. Cell beta-actinin appears to be present in various tissues of rat, rabbit, chicken, and pig. Cell beta-actinin is thought to function as an accelerator of actin polymerization in nonmuscle cells, in which actin monomers are abundantly present.
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