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Sequential postmortem changes of glomeruli. Their detection by scanning electron microscopy.

P C Langlinais

    Archives of Pathology & Laboratory Medicine
    |September 1, 1981
    PubMed
    Summary
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    Scanning electron microscopy (SEM) revealed six distinct postmortem changes in animal renal glomeruli up to 24 hours after death. Kidney tissue is suitable for SEM evaluation within 60 minutes postmortem.

    Area of Science:

    • Veterinary Pathology
    • Renal Histology
    • Electron Microscopy

    Background:

    • Understanding postmortem changes in animal renal tissue is crucial for accurate histopathological diagnosis.
    • Previous studies have not comprehensively detailed the morphological alterations in glomeruli over time after death.

    Purpose of the Study:

    • To characterize the morphological changes in renal glomeruli of five animal species using scanning electron microscopy (SEM) at various postmortem intervals.
    • To determine the optimal postmortem window for reliable SEM-based renal tissue evaluation.

    Main Methods:

    • Renal tissue specimens were collected from five animal species at intervals up to 24 hours postmortem.
    • Scanning electron microscopy (SEM) was employed to examine detailed glomerular ultrastructure.

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  • Morphological alterations were systematically identified and documented.

    • Main Results:

    • Six distinct glomerular alterations were observed, including capillary loop constriction, microvillus changes, podocyte blebs, pedicel swelling/fusion, podocyte erosion, and pedicel loss.
    • Glomerular size remained relatively constant across all species and time points.
    • Significant morphological changes occurred within the first 60 minutes postmortem.

    Conclusions:

    • SEM is a valuable tool for studying postmortem renal changes.
    • Reliable pathological evaluation of kidney tissue using SEM is feasible up to 60 minutes after death.
    • The identified glomerular alterations provide insights into early postmortem renal tissue degradation.