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Proliferative fasciitis: ultrastructural study of two cases
Abstract:
Two cases of proliferative fasciitis were studied by light and electron microscopy. The light microscopic features appear to be identical to those of proliferative myositis. Ultrastructural features include numerous cytoplasmic thin filaments, with occasional dense bodies, abundant rough endoplasmic reticulum, and cellular membrane-based vesicles. No Z bands or specialized cell junctions were identified. These findings suggest that the large balloon cells characteristic of the lesion probably are of myofibroblastic origin.
Insights
Proliferative fasciitis and myositis share similar light microscopy features. Ultrastructural analysis suggests the characteristic cells in proliferative fasciitis originate from myofibroblasts.
Area of Science:
- Pathology
- Cell Biology
- Histology
Background:
- Proliferative fasciitis is a rare benign soft tissue proliferation.
- Distinguishing proliferative fasciitis from other soft tissue lesions can be challenging.
- Understanding the cellular origin of proliferative fasciitis is crucial for accurate diagnosis.