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Related Experiment Videos

Iron studies in hemophilia.

R Lottenberg, C S Kitchens, G S Roessler

    Archives of Pathology & Laboratory Medicine
    |December 1, 1981
    PubMed
    Summary

    Hemophiliacs may develop iron deficiency due to reduced marrow iron stores, not occult blood loss. Iron may be sequestered in tissues like synovial membranes.

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    Area of Science:

    • Hematology
    • Internal Medicine
    • Nutritional Science

    Background:

    • Iron deficiency is not typically associated with hemophilia.
    • The potential for chronic iron deficiency in hemophiliacs due to occult blood loss was investigated.

    Purpose of the Study:

    • To determine if hemophiliacs experience excessive blood loss through urine or stool, leading to iron deficiency.
    • To assess iron status and body iron stores in patients with hemophilia.

    Main Methods:

    • Studied seven men with factor VII deficiency and one with factor IX deficiency.
    • Analyzed blood, bone marrow aspirates, urine, and stool samples.
    • Performed ferrokinetics and total-body counting for up to five months.

    Main Results:

    • No excessive blood loss was detected in urine or stool during the study period.
    • Bone marrow iron stores were significantly decreased in most subjects.
    • Iron stores were completely absent in four out of the eight participants.

    Conclusions:

    • Occult gastrointestinal or urinary blood loss is unlikely to be the primary cause of iron deficiency in hemophiliacs.
    • Reduced bone marrow iron stores suggest an alternative mechanism for iron deficiency in some hemophilia patients.
    • Iron may be sequestered in tissues, such as synovial membranes, contributing to a perceived or actual decrease in readily available body iron stores.

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