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Related Experiment Videos

Spinal narcotics and central nervous system depression.

A Sidi, J T Davidson, M Behar

    Anaesthesia
    |November 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

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    Central nervous system depression occurred 7 hours after intrathecal morphine. Delayed onset of side effects from intrathecal opioids requires careful patient monitoring.

    Area of Science:

    • Anesthesiology
    • Pharmacology
    • Neuroscience

    Background:

    • Intrathecal (IT) opioid administration is used for potent analgesia.
    • Delayed onset of central nervous system (CNS) depression is a known risk.
    • Morphine is a commonly used opioid for IT administration.

    Observation:

    • A case of delayed CNS depression 7 hours post-IT morphine injection is presented.
    • The patient experienced coma, bradypnea, and pinpoint pupils.
    • Initial naloxone administration was ineffective.

    Findings:

    • Delayed CNS depression following IT morphine can occur.
    • The typical onset of adverse effects may be significantly delayed.
    • Prolonged analgesia (126 hours) was achieved without additional analgesics.

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    Implications:

    • Awareness of delayed CNS depression is crucial for patient safety.
    • Monitoring for respiratory depression should extend beyond the immediate postoperative period.
    • Strategies like using hyperbaric solutions and maintaining a head-up position may mitigate risks.