Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Superoxide dismutase activity of macrocyclic polyamine complexes.

E Kimura, A Sakonaka, M Nakamoto

    Biochimica Et Biophysica Acta
    |December 4, 1981
    PubMed
    Summary

    New copper and nickel complexes show potent superoxide dismutase activity, outperforming existing scavengers. The nickel(II) complex NiH-2L is the most effective among those studied.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Vancomycin population pharmacokinetics for adult patients with sepsis or septic shock: are current dosing regimens sufficient?

    European journal of clinical pharmacology·2019
    Same author

    Cereal Intake Increases and Dairy Products Decrease Risk of Cognitive Decline among Elderly Female Japanese.

    The journal of prevention of Alzheimer's disease·2017
    Same author

    Glutamate Overproduction in Corynebacterium glutamicum Triggered by a Decrease in the Level of a Complex Comprising DtsR and a Biotin-containing Subunit.

    Bioscience, biotechnology, and biochemistry·2016
    Same author

    Age-related Changes in Energy Intake and Weight in Community-dwelling Middle-aged and Elderly Japanese.

    The journal of nutrition, health & aging·2016
    Same author

    Geophysics. Migrating tremor off southern Kyushu as evidence for slow slip of a shallow subduction interface.

    Science (New York, N.Y.)·2015
    Same author

    Clinicians' prescribing practices for bariatric surgery patients: is there an issue?

    Journal of clinical pharmacy and therapeutics·2014

    Area of Science:

    • Bioinorganic Chemistry
    • Medicinal Chemistry
    • Biochemistry

    Background:

    • Superoxide radicals (O2-) are reactive oxygen species implicated in cellular damage.
    • Xanthine oxidase and superoxide generation are key pathways in oxidative stress.
    • Developing effective superoxide dismutase (SOD) mimics is crucial for therapeutic interventions.

    Purpose of the Study:

    • To synthesize and characterize novel macrocyclic polyamine metal complexes.
    • To evaluate the superoxide scavenging activity of these complexes.
    • To identify the structural features that contribute to enhanced SOD-like activity.

    Main Methods:

    • Synthesis of copper(II) and nickel(II) macrocyclic polyamine complexes.
    • Assay of xanthine-xanthine oxidase-mediated nitroblue tetrazolium reduction.
    • Assessment of formazan formation inhibition by potassium superoxide.
    • Structure-activity relationship analysis based on macrocycle properties.

    Main Results:

    • Complexes demonstrated significant suppression of superoxide radical formation.
    • Activity varied with macrocycle ring size, donor atoms, metal ion, and substituents.
    • Several complexes exhibited higher O2- scavenging efficacy than copper(II)-salicylate and copper(II)-amino acid complexes.
    • Nickel(II)-naphthylmethyl-dioxo-[16]ane N5, 13, 1:1 complex (NiH-2L) was the most potent scavenger.

    Conclusions:

    • Macrocyclic polyamine metal complexes are effective superoxide dismutase mimics.
    • Structural modifications of macrocycles can significantly enhance antioxidant activity.
    • NiH-2L represents a promising candidate for further investigation as an antioxidant therapeutic agent.

    Related Experiment Videos