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DSIP-like immunoreactivity in the developing rat brain.

A J Kastin, C Nissen, D H Coy

    Brain Research Bulletin
    |December 1, 1981
    PubMed
    Summary
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    Delta sleep-inducing peptide (DSIP) is present in developing rat brains, with levels increasing before birth and around postnatal day 20. This peptide is available to rats throughout early development, regardless of its specific function.

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Biochemistry

    Background:

    • Delta sleep-inducing peptide (DSIP) is a naturally occurring nonapeptide.
    • DSIP has been previously reported to influence sleep patterns.

    Purpose of the Study:

    • To measure the concentration of DSIP-like material in the developing rat brain.
    • To investigate the developmental timeline of DSIP presence in rat brain tissue.

    Main Methods:

    • Radioimmunoassay (RIA) was used to quantify DSIP-like immunoreactivity.
    • Brain tissue samples were collected from fetal and postnatal developing rats.

    Main Results:

    • DSIP-like immunoreactivity was detected in fetal rat brains, with elevated levels preceding birth.

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  • A significant increase in DSIP concentration was observed around postnatal day 20 in one experiment, though timing varied in a subsequent study.
  • No significant differences in DSIP levels were found in rats injected with DSIP two months prior or across different brain regions at postnatal day 20.

    • Conclusions:

    • DSIP is present and accessible in the rat brain during early development.
    • The developmental expression pattern of DSIP suggests a potential role during this critical period.