Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antitumor effect of tuftsin.

K Nishioka, G F Babcock, J H Phillips

    Molecular and Cellular Biochemistry
    |December 4, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Long-term orthognathic surgical outcomes in Treacher Collins patients.

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2015
    Same author

    Evidence for three types of human cytotoxic lymphocyte.

    Immunology today·2014
    Same author

    Lymphokine-activated killer cell activity Characteristics of effector cells and their progenitors in blood and spleen.

    Immunology today·2014
    Same author

    Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells.

    Mucosal immunology·2013
    Same author

    Paediatric craniofacial fibrous dysplasia: the Hospital for Sick Children experience and treatment philosophy.

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2013
    Same author

    Weil's disease; a report of 23 cases.

    The New England journal of medicine·2010

    Tuftsin, a naturally occurring peptide, shows promise as an immunotherapeutic agent against experimental tumors by activating cytotoxic leukocytes like macrophages and natural killer cells. Its non-toxic nature and ease of synthesis highlight its potential in cancer immunotherapy.

    Area of Science:

    • Immunology
    • Cancer Research
    • Peptide Therapeutics

    Background:

    • Tuftsin is a physiological tetrapeptide derived from immunoglobulin G (IgG).
    • It exhibits diverse immunopotentiating properties.
    • Tuftsin has demonstrated efficacy against experimental tumors like L1210 leukemia and Cloudman S-91 melanoma.

    Purpose of the Study:

    • To explore the potential of tuftsin as an antitumor immunotherapeutic agent.
    • To investigate the mechanism of action of tuftsin in activating immune cells.

    Main Methods:

    • Activation of various leukocyte types with tuftsin.
    • Monitoring tuftsin levels in biological fluids.
    • Chemical synthesis of tuftsin.

    Main Results:

    Related Experiment Videos

    • Tuftsin activates leukocytes, including macrophages, natural killer cells, and granulocytes, to become cytotoxic effector cells.
    • The exact sequence of tuftsin (Thr-Lys-Pro-Arg) is known.
    • Tuftsin is naturally occurring, relatively non-toxic, and can be synthesized.

    Conclusions:

    • Tuftsin holds significant, largely unrecognized potential as an antitumor immunopotentiating agent.
    • Its natural occurrence, safety profile, and synthetic accessibility make it a promising candidate for cancer immunotherapy.
    • Tuftsin's ability to control infectious diseases further underscores its potential as an immunomodulator.