Cottonseed oil as a vaginal contraceptive

The effect of gossypol acetic acid an cottonseed oil emulsion on human spermatozoal motility was tested. Contrary to a recent report [Waller et al. (1980): Contraception 22:183-187] that gossypol acetic acid is harmless to human spermatozoal motility in vitro, 10-3 M gossypol acetic acid completely abolished spermatozoal motility. This discrepancy might have stemmed from an oversight in the gossypol solubility. Cottonseed oil emulsion also exhibited spermatozoal motility inhibition. The applicability of this natural low toxicity cottonseed oil as vaginal contraceptive was explored