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Leukotrienes C and D induce bronchoconstriction in man.
Agents and Actions
|December 1, 1981
Summary
Synthetic leukotrienes C and D caused moderate bronchoconstriction and coughing in healthy individuals. The drug FPL 55712 effectively reduced these pulmonary responses, suggesting a potential therapeutic target.
Area of Science:
- Respiratory Medicine
- Pharmacology
Background:
- Leukotrienes are inflammatory mediators implicated in asthma.
- Synthetic leukotrienes C and D's effects on pulmonary function require further elucidation.
Purpose of the Study:
- To investigate the pulmonary responses to synthetic leukotrienes C and D in normal volunteers.
- To assess the efficacy of FPL 55712 in modulating these responses.
Main Methods:
- Two normal volunteers inhaled aerosols of synthetic leukotrienes C and D.
- Pulmonary function parameters, including FEV1 and expiratory flow at low lung volumes, were measured.
- The effect of FPL 55712 on leukotriene-induced responses was evaluated.
Main Results:
- Leukotrienes C and D were equipotent and equieffective in causing moderate bronchoconstriction and coughing.
- FEV1 changes were minimal, while expiratory flow reductions were significant at low lung volumes.
- FPL 55712 completely abolished the cough reflex and partially inhibited bronchoconstriction.
Conclusions:
- Synthetic leukotrienes C and D induce significant pulmonary responses in healthy individuals.
- FPL 55712 demonstrates potential as a therapeutic agent for leukotriene-mediated respiratory effects.