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Plasmacytomas in rhesus monkeys.

H Uno, T F Warner

    Archives of Pathology & Laboratory Medicine
    |June 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Two rhesus monkeys developed plasmacytomas, a type of plasma cell tumor. These tumors infiltrated various organs, including bone marrow, skin, kidney, stomach, and lymph nodes, showing IgA immunoglobulin production.

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    Area of Science:

    • Veterinary Pathology
    • Oncology
    • Immunology

    Background:

    • Plasmacytomas are neoplastic growths of plasma cells.
    • These tumors can occur in various species, including non-human primates.
    • Understanding plasmacytoma presentation in rhesus monkeys is crucial for comparative oncology.

    Purpose of the Study:

    • To report and characterize plasmacytomas in two adult male rhesus monkeys.
    • To investigate the histopathological and immunohistochemical features of these tumors.
    • To assess the involvement of immunoglobulin A (IgA) in the neoplastic plasma cells.

    Main Methods:

    • Histopathological examination using light microscopy.
    • Ultrastructural analysis via electron microscopy.
    • Immunohistochemical staining for IgA using immunoperoxidase technique.

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  • Detection of IgA in tumor extracts and serum.

    • Main Results:

    • Two cases of plasmacytoma were identified in adult male rhesus monkeys.
    • Tumor infiltration varied, affecting bone marrow, skin, kidney, soft tissues, stomach, lymph nodes, and retroperitoneum.
    • Both tumors were confirmed as typical plasmacytomas histologically.
    • Immunoreactivity for IgA was detected in tumor cells, with strong and weak staining in the respective cases.
    • IgA was also found in tumor extracts and serum of one monkey.

    Conclusions:

    • Rhesus monkeys can develop plasmacytomas with diverse organ involvement.
    • Histopathology and immunohistochemistry are essential for diagnosing plasmacytomas and assessing IgA production.
    • These findings contribute to the understanding of plasma cell neoplasms in non-human primates.