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Updated: Jan 13, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
Mutation rates from rare variants of proteins in Indian tribes
Abstract:
Recent attempts to estimate mutation rates in man have resulted in some theoretical developments. Recently, Nei (1977) provided a new formula for estimating mutation rates from electrophoretically detected rare protein variants. His formula is applied here to estimated mutation rates from such variants among the Kadars of Kerala and five tribes of Andhra Pradesh in India. The estimates seem to differ from Nei's estimate on South American Indians by an order of magnitude, although the standard errors associated with such estimates are rather large.
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