Related Experiment Video
Updated: Aug 17, 2026

Diagonal Method to Measure Synergy Among Any Number of Drugs
Published on: June 21, 2018
Logic-based program system for predicting drug interactions
Abstract:
This paper deals with the application of an AI language, based on mechanical theorem prover (PROLOG), to deduce drug interactions. One hundred and thirty-one drug interactions were predicted by logical deduction with a program system comprising about 52 drugs in practice and 32 independent possibilities of deduction. The database of the system contains the chemical and pharmaceutical characteristics of the active components of the drug preparations, and the deductions are based on general pharmacokinetic, pharmacodynamic or other biochemical relationships concerning interactions.
Related Concept Videos
Drug-Receptor Interactions
Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue.
Quantitative Aspects of Drug-Receptor Interaction
Agonism and Antagonism: Quantification
To quantify these effects, researchers use a dose-response curve, which provides valuable information about the potency and efficacy of a drug. Potency refers to...
Factors Affecting Protein-Drug Binding: Drug Interactions
Displacement interactions can have varying outcomes, ranging from toxicity to virtually...
Pharmacokinetics: Drug–Drug Interactions
Drug toxicity: Drug–Drug Interaction

