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Related Experiment Videos

Lithium and hypothyroidism.

V K Piziak, J E Sellman, E Othmer

    The Journal of Clinical Psychiatry
    |September 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Lithium treatment rarely causes hypothyroidism. This study found goiter in 0.3% and clinical hypothyroidism in 1-2% of patients, with TSH being the best test for thyroid function evaluation.

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    Area of Science:

    • Endocrinology
    • Psychiatry
    • Pharmacology

    Background:

    • Hypothyroidism is a potential adverse effect of lithium therapy.
    • The exact incidence and optimal monitoring methods for lithium-induced hypothyroidism remain unclear.

    Purpose of the Study:

    • To determine the incidence of lithium-related thyroid dysfunction.
    • To identify the most effective clinical and laboratory tests for monitoring thyroid function during lithium treatment.

    Main Methods:

    • Survey of 70 clinicians.
    • Chart review of 2,590 patients.
    • Review of the pathophysiology of lithium-induced hypothyroidism.

    Main Results:

    • Lithium-related thyroid dysfunction is uncommon.

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  • Incidence of goiter during lithium therapy: 0.3%.
  • Incidence of clinical hypothyroidism during lithium therapy: 1-2%.
  • Thyroid-stimulating hormone (TSH) is the most specific laboratory test for evaluating thyroid function.

    • Conclusions:

    • Lithium-induced hypothyroidism is not a common clinical problem.
    • TSH testing is recommended for monitoring thyroid function in patients on lithium therapy.