Related Experiment Videos
Flucloxacillin in bone.
Journal of Clinical Pathology
|August 1, 1978
Summary
Flucloxacillin administered intramuscularly achieved therapeutic concentrations in hip bone tissue for osteoarthritis surgery prophylaxis. Bone flucloxacillin levels were lower than serum, but significant, aiding infection prevention strategies.
Area of Science:
- Orthopedics
- Infectious Disease Pharmacology
Background:
- Total hip replacement (THR) for osteoarthritis necessitates effective perioperative antibiotic prophylaxis.
- Flucloxacillin is commonly used, but its penetration into bone tissue requires further investigation.
Purpose of the Study:
- To quantify flucloxacillin concentrations in human serum and bone tissue (trabecular and compact) following intramuscular administration before THR.
Main Methods:
- Ten patients received intramuscular flucloxacillin 2 hours preoperatively.
- Bone and serum samples were collected during surgery.
- Flucloxacillin concentrations were determined using a well-diffusion assay.
Main Results:
- Mean serum flucloxacillin concentration was 8.9 mg/l.
- Mean concentrations in trabecular and compact bone washings were 1.3 mg/l and 0.9 mg/l, respectively.
- Blood contamination accounted for a maximum of 26% of bone flucloxacillin.
Conclusions:
- Intramuscular flucloxacillin achieves measurable concentrations in hip bone, supporting its prophylactic role in THR.
- Further research may optimize dosing for enhanced bone penetration and infection prevention.