Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Quantitative histology in giardiasis.

S G Wright, A M Tomkins

    Journal of Clinical Pathology
    |August 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Giardia lamblia infection causes significant intestinal damage, impacting surface area and absorption. Treatment effectiveness varied, with metronidazole and mepacrine showing positive histological changes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Impact of zinc supplementation on subsequent morbidity and growth in Bangladeshi children with persistent diarrhoea.

    Journal of health, population, and nutrition·2007
    Same author

    HIV and syphilis in young Chinese adults: implications for spread.

    International journal of STD & AIDS·2005
    Same author

    Attitudes to HIV and HIV testing in high prevalence areas of China: informing the introduction of voluntary counselling and testing programmes.

    Sexually transmitted infections·2005
    Same author

    Case reports: acute hookworm infection: an unusual cause of profuse watery diarrhoea in returned travellers.

    Transactions of the Royal Society of Tropical Medicine and Hygiene·2004
    Same author

    [Vitamin A and intrauterine growth retardation].

    Jornal de pediatria·2003
    Same author

    A study of 235 cases of human brucellosis in Sana'a, Republic of Yemen.

    Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit·2003
    Same journal

    HER2-low as a unique subgroup in breast cancer: insights from neoadjuvant chemotherapy response and survival analysis.

    Journal of clinical pathology·2026
    Same journal

    Polyp-forming Dieulafoy lesion of the rectum.

    Journal of clinical pathology·2026
    Same journal

    Defining biochemical, pathological and molecular factors prognostic in terms of disease control and survival in high-grade extremity soft tissue sarcoma: a scoping review.

    Journal of clinical pathology·2026
    Same journal

    MILGDF: a multi-task, instance-level supervised model for oral squamous cell carcinoma integrating local-global attention and dynamic decision fusion.

    Journal of clinical pathology·2026
    Same journal

    Paediatric B-lymphoblastic leukaemia with low peripheral blasts: a potential diagnostic pitfall.

    Journal of clinical pathology·2026
    Same journal

    MRI-targeted versus systematic needle core biopsies in prostate cancer: a patient-based analysis of potential diagnostic and biologic underestimation.

    Journal of clinical pathology·2026
    See all related articles

    Area of Science:

    • Gastroenterology
    • Parasitology
    • Histopathology

    Background:

    • Giardia lamblia infections commonly lead to malabsorption.
    • Assessing histological changes in the proximal jejunum is crucial for understanding infection severity.

    Purpose of the Study:

    • To quantitatively assess histological changes in the proximal jejunum of patients with Giardia lamblia infections using the Weibel graticule.
    • To correlate histological findings with malabsorption parameters and treatment outcomes.

    Main Methods:

    • Quantitative histological assessment of proximal jejunal mucosal biopsies using the Weibel graticule.
    • Measurement of surface area (SA) and correlation with D-xylose excretion and fecal fat output.
    • Comparison of SA measurements between infected patients and controls, and assessment of treatment effects.

    Related Experiment Videos

    Main Results:

    • Significant reduction in mean surface area (SA) in patients with giardiasis and malabsorption compared to controls.
    • SA measurements strongly correlated with malabsorption indicators (D-xylose excretion, fecal fat output).
    • Metronidazole and mepacrine treatments led to significant SA increase, unlike tetracycline.

    Conclusions:

    • The Weibel graticule is effective for quantifying jejunal histological damage in giardiasis.
    • Histological and functional impairments are most severe early post-infection and may resolve over time.
    • Treatment response varies, with some drugs promoting significant mucosal recovery.