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Immune complexes in Sjögren's syndrome.

M Fischbach, D Char, M Christensen

Arthritis and Rheumatism

|July 1, 1980

Summary

Immune complexes were not correlated with Sjögren's syndrome severity or lymphoma development in patients. Levels remained stable, suggesting limited involvement in disease progression or activity.

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Area of Science:

Immunology
Rheumatology
Pathology

Background:

Sjögren's syndrome is an autoimmune disorder characterized by lymphocytic infiltration of exocrine glands.
Immune complexes are implicated in various autoimmune diseases, but their role in Sjögren's syndrome is not fully understood.

Purpose of the Study:

To investigate the presence and significance of immune complexes in patients with Sjögren's syndrome.
To determine if immune complex levels correlate with disease activity, glandular pathology, or the development of lymphoma.

Main Methods:

Sera from 48 Sjögren's syndrome patients were analyzed for immune complexes using the Raji cell assay.
Serum complement levels were assessed.
Five patients were monitored serially during the progression to pseudolymphoma or malignant lymphoma.

Main Results:

No correlation was found between immune complex levels and the degree of lymphocytic infiltration in labial salivary glands.
Serum complement levels were within the normal range for all patients.
In four of five serially followed patients, immune complex levels remained largely unchanged and did not parallel disease activity, rheumatoid factor, or SS-A/SS-B antibody concentrations.

Conclusions:

Immune complexes do not appear to be a significant factor correlating with the severity of labial gland infiltration in Sjögren's syndrome.
Immune complex levels do not consistently track disease activity or the development of lymphoma in this patient cohort.
The role of immune complexes in the pathogenesis of Sjögren's syndrome warrants further investigation.

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