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Updated: Aug 5, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

[A benign form of rheumatoid arthritis, associated with low IgG, IgM and IgA and C3-proactivator concentrations in

B Stojan, F Hasler

    Zeitschrift Fur Rheumatologie
    |May 1, 1980
    PubMed

    Insights

    Patients with rheumatoid arthritis and low immunoglobulin levels exhibit better functional capacity and less joint damage. This suggests immunoglobulin levels may predict rheumatoid arthritis disease progression and severity.

    Area of Science:

    • Immunology
    • Rheumatology

    Context:

    • Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation.
    • Disease severity and progression in RA can vary significantly among patients.
    • Immunoglobulin levels and complement components are implicated in autoimmune processes.

    Purpose:

    • To investigate the correlation between immunoglobulin levels and C3-proactivator and the clinical manifestations and disease progression in rheumatoid arthritis patients.
    • To determine if lower immunoglobulin levels are associated with a more benign course of rheumatoid arthritis.

    Summary:

    • This study analyzed 31 rheumatoid arthritis patients, assessing immunoglobulin G (IgG), immunoglobulin A (IgA), immunoglobulin M (IgM), and C3-proactivator levels.
    • Patients with lower levels of these markers demonstrated significantly better functional capacity (Steinbrocker scale) and reduced synovitis, erosions, and joint destruction.
    • Despite a longer disease duration, patients with low immunoglobulin levels (IgG < 1000 mg/100 ml) showed a more favorable disease course compared to those with higher levels.

    Impact:

    • Identifies potential biomarkers (immunoglobulin levels) for predicting rheumatoid arthritis disease activity and prognosis.
    • Suggests that low immunoglobulin levels may indicate a less aggressive form of rheumatoid arthritis.
    • Provides insights into the immunopathogenesis of rheumatoid arthritis and potential therapeutic targets.

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