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Related Experiment Videos

Inflammatory and immune cell function in psoriasis: II. Monocyte function, lymphokine production.

G G Krueger, W W Jederberg, B E Ogden

    The Journal of Investigative Dermatology
    |September 1, 1978
    PubMed
    Summary

    Psoriasis patients show altered immune cell function, with reduced lymphokine release and increased monocyte migration to chemotactic factors. These findings suggest an inherent metabolic disorder in psoriatic monocytes.

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    Long-term efficacy and safety of ustekinumab, with and without dosing adjustment, in patients with moderate-to-severe psoriasis: results from the PHOENIX 2 study through 5 years of follow-up.

    The British journal of dermatology·2014

    Area of Science:

    • Immunology
    • Dermatology
    • Cell Biology

    Background:

    • Psoriasis is associated with altered cell-mediated immune responses.
    • Previous research confirmed immune dysregulation in psoriasis patients.

    Purpose of the Study:

    • To investigate in vitro immune cell function in psoriasis.
    • To explore lymphokine release and monocyte migration patterns in psoriatic subjects.

    Main Methods:

    • Assessed lymphokine release from antigen-stimulated and control lymphocytes.
    • Measured monocyte migration in response to complement-derived and lymphocyte-derived chemotactic factors.
    • Evaluated nitroblue tetrazolium reduction by monocytes from psoriatic and normal subjects.

    Main Results:

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    • Lymphokine release was decreased in psoriatic lymphocytes compared to normal subjects.
    • Monocyte migration to chemotactic factors was significantly increased in psoriatic subjects.
    • Psoriatic monocytes exhibited enhanced nitroblue tetrazolium reduction, indicating altered metabolic activity.

    Conclusions:

    • Monocytes from psoriasis patients display functional alterations.
    • These alterations suggest an inherent metabolic disorder in psoriatic monocytes.
    • Immune cell dysfunction in psoriasis may extend beyond active disease states.