Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Serum immunoglobulin E in pemphigus.

G R Bruns, R J Ablin, P D Guinan

The Journal of Investigative Dermatology

|September 1, 1978

Summary

This summary is machine-generated.

Brazilian pemphigus foliaceus (BPF) patients show significantly higher immunoglobulin E (IgE) levels than pemphigus vulgaris (PV) patients and healthy individuals. This finding suggests potential links between elevated IgE and BPF

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Immunosuppression by seminal plasma.

Immunology today·2014

Same author

The role of neuroendocrine cells in prostate cancer: a comprehensive review of current literature and subsequent rationale to broaden and integrate current treatment modalities.

Current medicinal chemistry·2013

Same author

Retinoids, vitamin D, invasion, and metastasis.

Current oncology (Toronto, Ont.)·2012

Same author

The role of transglutaminases in the pathophysiology of prostate cancer.

Current oncology (Toronto, Ont.)·2011

Same author

Screening for prostate cancer: Controversy? What controversy?

Current oncology (Toronto, Ont.)·2009

Same author

PSA assays.

The Lancet. Oncology·2002

Same journal

An Integrated Skin Cell Atlas Decodes the Pilosebaceous Unit.

The Journal of investigative dermatology·2026

Same journal

Residual CSB activity explains mild UV-sensitive syndrome phenotype caused by CSB mutations.

The Journal of investigative dermatology·2026

Same journal

Charting a new melanoma risk factor: Satellite Naevus Prevalence in High-Risk and Population-Based Cohorts.

The Journal of investigative dermatology·2026

Same journal

Human keratinocytes and fibroblasts coordinate early cutaneous innate defenses against Candida auris.

The Journal of investigative dermatology·2026

Same journal

Merkel cells attenuate autoantigen-specific T cell driven skin inflammation in mice associated with reduced neutrophil recruitment.

The Journal of investigative dermatology·2026

Same journal

The response of human melanocytic nevi to simulated solar radiation assessed by single-nucleus RNA sequencing of frozen tissue.

The Journal of investigative dermatology·2026

See all related articles

Area of Science:

Immunology
Dermatology
Autoimmune Diseases

Background:

Pemphigus is a group of autoimmune blistering diseases affecting the skin and mucous membranes.
Brazilian pemphigus foliaceus (BPF) and pemphigus vulgaris (PV) are distinct subtypes with differing clinical and immunological characteristics.
Immunoglobulin E (IgE) plays a role in allergic reactions and parasitic infections, but its role in pemphigus is less understood.

Purpose of the Study:

To compare immunoglobulin E (IgE) levels in patients with Brazilian pemphigus foliaceus (BPF) and pemphigus vulgaris (PV).
To investigate the potential association between elevated IgE levels and the immunologic aberrations observed in BPF.
To explore the implications of increased IgE in the context of a suggested infectious etiology for BPF.

Main Methods:

Related Experiment Videos

Serum samples were collected from patients diagnosed with BPF (n=12) and PV (n=11).
A solid-phase radioimmunoassay technique was employed to quantify IgE levels in patient sera.
IgE levels were compared between BPF patients, PV patients, and a control group of healthy adults.

Main Results:

A statistically significant elevation in serum IgE levels was observed in patients with BPF.
IgE levels in BPF patients were significantly higher compared to those in PV patients.
BPF patients exhibited higher IgE levels than the healthy adult control group.

Conclusions:

Elevated serum IgE levels are a characteristic feature of Brazilian pemphigus foliaceus (BPF).
The increased IgE in BPF may be linked to aberrant immune responses or an infectious trigger.
Further research is warranted to elucidate the precise role of IgE in the pathogenesis of BPF.