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Macular holes.

M James, S S Feman

    Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe'S Archive for Clinical and Experimental Ophthalmology
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    This study followed 24 eyes with full-thickness macular holes, finding a high incidence of systemic estrogen therapy. Most cases remained stable, suggesting potential links between estrogen and macular hole progression.

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    Area of Science:

    • Ophthalmology
    • Retinal Diseases

    Background:

    • Macular holes are a common cause of vision loss.
    • Posterior vitreous separation is often associated with macular holes.

    Purpose of the Study:

    • To investigate the clinical course of full-thickness macular holes.
    • To identify potential risk factors or associations in patients with macular holes.

    Main Methods:

    • Prospective follow-up of 24 eyes with clinically diagnosed full-thickness macular holes.
    • Documentation of retinal detachment, posterior vitreous separation, refractive error, and progression.
    • Review of patient history for systemic therapies.

    Main Results:

    • All macular holes were full-thickness with associated retinal detachment and posterior vitreous separation.

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  • Most eyes (23/24) were within three diopters of emmetropia.
  • Only one eye showed progression of retinal detachment.
  • A high incidence of systemic estrogen therapy was observed in the patient cohort.

    • Conclusions:

    • Full-thickness macular holes with associated retinal detachment and posterior vitreous separation may have a stable clinical course in many cases.
    • Systemic estrogen therapy may be a notable factor in patients with macular holes.
    • Further research is warranted to explore the relationship between estrogen and macular hole development/progression.