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Human nerve excitability.

R E Powers, H M Swick, M P McQuillen

    Journal of Neurology, Neurosurgery, and Psychiatry
    |July 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Nerve excitability in healthy subjects was studied using electrical stimulation. Strength-duration curves for different nerve fiber types showed no significant variations, suggesting excitability reflects factors beyond myelin.

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    Area of Science:

    • Neuroscience
    • Electrophysiology
    • Peripheral Nerve Function

    Background:

    • Understanding peripheral nerve excitability is crucial for diagnosing neurological disorders.
    • Previous research has explored nerve excitability, but comprehensive analysis across different nerve populations and locations is limited.

    Purpose of the Study:

    • To investigate and characterize the excitability of various peripheral nerve fiber populations in healthy individuals.
    • To determine if nerve excitability varies significantly across different nerve types (ulnar, posterior tibial, peroneal, sural), locations (upper vs. extremity), or over time.

    Main Methods:

    • Electrical stimulation using square wave stimuli of varying durations was applied to peripheral nerves (ulnar, posterior tibial, peroneal, sural) in healthy subjects.
    • Evoked muscle or nerve action potentials were recorded to derive "threshold" strength-duration curves.

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  • Data were analyzed to compare curves across different fiber populations (motor, sensory, mixed) and experimental conditions.

    • Main Results:

    • Strength-duration curves for motor, sensory, and mixed nerve fiber populations did not show significant variations among themselves.
    • No significant differences in excitability were observed between upper and extremity nerve locations.
    • Nerve excitability did not change significantly over time in the tested subjects.
    • No correlations were found between nerve excitability and other standard measures of peripheral nerve function.

    Conclusions:

    • Peripheral nerve excitability, as measured by strength-duration curves, is remarkably consistent across different fiber types and locations in healthy individuals.
    • The findings suggest that nerve excitability reflects underlying nerve structure or function independent of myelin.
    • Further research is warranted to elucidate the specific structural or functional elements contributing to nerve excitability.