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Spinal evoked potentials in the primate: neural substrate.

J F Cusick, J Myklebust, S J Larson

    Journal of Neurosurgery
    |October 1, 1978
    PubMed
    Summary
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    Spinal evoked potentials recorded rostrally originate from the dorsal columns. Resection of these pathways, but not others, eliminated the recorded responses, confirming their exclusive origin.

    Area of Science:

    • Neuroscience
    • Spinal Cord Physiology

    Background:

    • Peripheral nerve stimulation generates electrical signals that travel through the spinal cord.
    • Understanding the specific pathways responsible for transmitting these signals is crucial for interpreting neurological function.

    Purpose of the Study:

    • To determine the exclusive origin of spinal evoked potentials recorded at levels rostral to peripheral nerve stimulation.
    • To investigate the role of specific spinal cord tracts in transmitting these evoked potentials.

    Main Methods:

    • Recording summated responses via epidural and subdural electrodes in monkeys following peripheral nerve stimulation.
    • Performing segmental microsurgical resections of the dorsal columns at thoracic and cervical levels.
    • Assessing the impact of isolated dorsal column preservation and bilateral dorsolateral column resection on evoked potentials.

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    Main Results:

    • Microsurgical resection of dorsal columns at thoracic and cervical levels completely abolished evoked potentials recorded rostral to the lesions.
    • Preservation of isolated dorsal column segments did not significantly alter response latency or waveform.
    • Bilateral dorsolateral column resection showed no discernible effect on these responses.

    Conclusions:

    • Spinal evoked potentials recorded rostral to the nerve root entry zones are almost exclusively mediated by the dorsal columns.
    • This finding highlights the critical role of the dorsal columns in transmitting sensory information rostrally within the spinal cord.