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Dose-related interaction between timolol and adrenaline.

A Ohrström

    Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe'S Archive for Clinical and Experimental Ophthalmology
    |January 1, 1981
    PubMed
    Summary
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    Adrenaline eye drops combined with oral timolol maleate showed varied intraocular pressure (IOP) effects. Lower timolol doses enhanced adrenaline

    Area of Science:

    • Ophthalmology
    • Pharmacology

    Background:

    • Intraocular pressure (IOP) management is crucial for preventing glaucoma progression.
    • Timolol maleate and adrenaline are commonly used ophthalmic agents.
    • Understanding drug interactions is vital for effective IOP control.

    Purpose of the Study:

    • To investigate the combined effects of oral timolol maleate and topical adrenaline on intraocular pressure (IOP).
    • To determine if timolol dosage influences the interaction between timolol and adrenaline on IOP.

    Main Methods:

    • A double-blind, randomized trial was conducted with healthy volunteers.
    • Participants received oral timolol maleate in two doses (20 mg and 5 mg daily).
    • One eye received 1% adrenaline eye drops, while the other received a placebo.

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    Main Results:

    • Adrenaline demonstrated a significant additive effect on IOP reduction with the lower dose of timolol (5 mg).
    • Conversely, with the higher dose of timolol (20 mg), adrenaline exhibited an antagonistic effect on IOP reduction.
    • These findings suggest a dose-dependent interaction between timolol and adrenaline.

    Conclusions:

    • The interaction between timolol maleate and adrenaline on IOP is dose-dependent.
    • Incomplete beta-blockade at lower timolol doses may explain the additive effect with adrenaline.
    • Complete beta-blockade at higher timolol doses might lead to the antagonistic effect observed with adrenaline.