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Related Experiment Videos

Changes in theophylline clearance during acute illness.

S Vozeh, J R Powell, S Riegelman

    JAMA
    |October 20, 1978
    PubMed
    Summary

    Theophylline clearance can fluctuate significantly in patients hospitalized with acute illnesses. Close monitoring of theophylline levels is crucial for safe and effective treatment adjustments.

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    POPULATION GENETICS OF MEXICAN DROSOPHILA VI. CYTOGENETIC ASPECTS OF THE INVERSION POLYMORPHISM IN DROSOPHILA PSEUDOOBSCURA.

    Evolution; international journal of organic evolution·2017

    Area of Science:

    • Pharmacokinetics
    • Clinical Pharmacology
    • Critical Care Medicine

    Background:

    • Theophylline is a medication used to treat respiratory diseases.
    • Maintaining therapeutic theophylline levels is essential for efficacy and safety.
    • Acute illnesses can impact drug metabolism and clearance.

    Observation:

    • Observed significant (twofold to threefold) variability in total-body theophylline clearance in three hospitalized patients.
    • These pharmacokinetic changes correlated with clinical status fluctuations during acute illness.

    Findings:

    • Theophylline clearance decreased in a patient with worsening airway obstruction.
    • Theophylline clearance increased in patients with resolving pneumonia and improving congestive heart failure.
    • Total-body theophylline clearance demonstrated instability during acute, severe illness.

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    Implications:

    • Highlights the potential for rapid theophylline dose adjustments in acute illness.
    • Emphasizes the need for vigilant plasma theophylline concentration monitoring in hospitalized patients.
    • Suggests that acute conditions significantly influence theophylline pharmacokinetics, requiring personalized dosing strategies.