Biological role of the pars intermedia in lower vertebrates

The most obvious function of the pars intermedia in lower vertebrates is the secretion of melanocyte-stimulating hormone (MSH) for the purpose of pigmentary control. In some amphibia, elasmobranchs and teleosts, the histological study of the pars intermedia, the radioimmunoassay of pituitary and plasma MSH and the effects of hypophysectomy and of MSH injection suggest that the activity of the pars intermedia is regulated to satisfy the needs of cryptic colour change. MSH secretion is associated with dispersion of melanin granules and with melanogenesis. However, in other teleost species, both the evidence from pituitary cytology and the failure to respond to MSH injection suggest that pigmentary change is not regulated by changes in the plasma titres of MSH. Results discussed here indicate that MSH alone may be inadequate for pigmentary control. Evidence for non-pigmentary functions of the pars intermedia is circumstantial and fragmentary. It is based on cytological observations of altered pars intermedia activity under certain conditions, and on observations of physiological changes that accompany increased melanotropic activity. Such function include effects of plasmas titres of cortisol in teleosts, resistance to adrenaline-induced hyperglycaemia in toads, and effects on neural activity in fish and amphibia. Evidence for pars intermedia involvement in osmoregulation is briefly discussed.