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Related Experiment Videos

Development of enteric neurons from non-recognizable precursor cells.

M D Gershon, G Teitelman, T P Rothman

    Ciba Foundation Symposium
    |January 1, 1981
    PubMed
    Summary
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    Developing gut neurons arise from a persistent pool of precursors that can transiently express phenotypes. Gestational changes influence these precursors, generating diverse enteric neurons and supporting neuron generation.

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Gastroenterology

    Background:

    • Enteric ganglia neurons lack distinct morphology upon gut entry.
    • The developing gut harbors immature, proliferating neuronal precursors.

    Purpose of the Study:

    • Investigate the origin and development of enteric neurons.
    • Understand the generation of enteric neuronal diversity.

    Main Methods:

    • Organotypic culture of embryonic gut explants before neuronal appearance.
    • Analysis of neuronal phenotypes, including cholinergic, serotonergic, and catecholaminergic expression.

    Main Results:

    • Cultured embryonic gut developed a myenteric plexus with cholinergic and serotonergic neurons.

    Related Experiment Videos

  • Neuronal precursors exhibit transient phenotypes, exemplified by catecholaminergic expression.
  • Sequential changes in the microenvironment likely drive neuronal diversity.

    • Conclusions:

    • A persistent pool of neuronal precursors contributes to enteric nervous system development.
    • Gestational age and microenvironmental interactions are crucial for enteric neuron diversity.
    • The proliferative capacity of precursors supports the generation of numerous enteric neurons.