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[Changes in the drug resistance of bacteria from peripheral infections after 5 years]
Abstract:
The reports of outpatients with surgical infections of the years 1972 and 1977 are compared to demonstrate changes in composition of the spectrum and resistance to antibiotics. In the first period 425 cases could be used for study, in the second only 132 cases could be traced. In the second period phlegmonous infections, caused by streptococci were twice as frequent as in 1972. In the same year resistance of staphylococci to Penicillin was found in 43% of the cases. Five years later no more resistance was present and in 28,8% Penicillin even proved to be the most efficient drug. Likewise the streptococci had become more sensitive to Penicillin in the second period, but Cephalosporin remained the treatment of choice for this type of infections. Gram negative germs as B. coli were found much less in 1977 than five years before and their sensibility to sulfamethoxazol-trimethoprim was remarkably higher. The study demonstrates the changes in antibiotic resistance of a given germ population as well as the need for close observation of these changes. Standard antibiotic treatment has to be adapted to the modifications of germ behavior.
Insights
Antibiotic resistance in surgical infections has changed significantly. Studies from 1972 and 1977 show shifts in bacterial susceptibility, necessitating updated treatment protocols for effective patient care.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Clinical Pharmacy
Context:
- Comparison of outpatient surgical infection data from 1972 and 1977.
- Analysis of changes in bacterial spectrum and antibiotic resistance patterns.
- Evaluation of 425 cases from 1972 and 132 cases from 1977.
Purpose:
- To demonstrate the evolution of bacterial composition and antibiotic resistance in surgical infections over a five-year period.
- To identify trends in microbial susceptibility to commonly used antibiotics.
- To inform clinical practice regarding appropriate antibiotic selection.
Summary:
- Phlegmonous infections caused by streptococci doubled in frequency from 1972 to 1977.
- Staphylococcal resistance to penicillin decreased significantly, with penicillin becoming more effective by 1977.
- Gram-negative bacteria like B. coli decreased, showing increased sensitivity to sulfamethoxazole-trimethoprim.
Impact:
- Highlights the dynamic nature of antibiotic resistance in bacterial populations.
- Underscores the critical need for continuous monitoring of antimicrobial susceptibility.
- Emphasizes the necessity of adapting standard antibiotic treatments to evolving microbial behavior for improved therapeutic outcomes.