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Properdin factor B polymorphism in Black Americans.

B Budowle, R C Go, B O Barger

    Journal of Immunogenetics
    |December 1, 1981
    PubMed
    Summary
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    Properdin factor B (Bf) gene frequencies in southeastern US Black individuals were analyzed. Findings reveal distinct Bf allele distributions compared to other Black populations, potentially due to differing racial admixture.

    Area of Science:

    • Population Genetics
    • Immunogenetics
    • Human Molecular Anthropology

    Background:

    • Properdin factor B (Bf) is a complement system protein encoded by a genetically controlled polymorphic gene.
    • Understanding Bf gene frequencies is crucial for population genetics and anthropological studies.
    • Previous studies have established Bf allele frequencies in various global populations.

    Purpose of the Study:

    • To determine the specific allele frequencies of Properdin factor B (Bf) in a Black population from the southeastern United States.
    • To compare these frequencies with those reported in other Black populations globally.
    • To investigate potential correlations between observed Bf gene frequency variations and historical population admixture.

    Main Methods:

    • Agarose gel electrophoresis was employed to phenotype Properdin factor B (Bf) variants.

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  • Genotyping was performed on a cohort of 194 Black individuals from the southeastern US.
  • Bf gene allele frequencies (Bf-F, Bf-S, Bf-F1, Bf-S1) were calculated from the phenotype data.

    • Main Results:

    • The determined allele frequencies for Bf-F, Bf-S, Bf-F1, and Bf-S1 in southeastern US Blacks were 0.626, 0.034, 0.013, and 0.027, respectively.
    • These Bf frequencies closely resemble those found in South African Black populations.
    • A significant difference was observed when comparing these frequencies to those of Black individuals from Boston, suggesting population-specific genetic variations.

    Conclusions:

    • The Bf gene frequencies in southeastern US Blacks align more closely with South African Blacks than with Boston Blacks.
    • The observed discrepancies may be attributed to differing degrees of historical racial admixture in these distinct geographic populations.
    • This study contributes to the understanding of human genetic diversity and the population-specific distribution of immune system-related genes.