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Related Experiment Videos

Alcohol and hypertension.

D G Beevers

    Lancet (London, England)
    |July 16, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Hypertensive patients showed higher liver enzyme levels, specifically alanine and aspartate aminotransferase, compared to normotensive individuals. Increased alcohol intake was associated with higher aminotransferase levels in hypertensive subjects.

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    Area of Science:

    • Cardiology
    • Hepatology
    • Clinical Biochemistry

    Background:

    • Hypertension is a prevalent cardiovascular risk factor.
    • Liver function abnormalities can be associated with various systemic diseases.
    • Elevated liver enzymes may indicate underlying hepatic or systemic issues.

    Purpose of the Study:

    • To compare liver function test results between hypertensive and normotensive individuals.
    • To investigate the relationship between hypertension and specific liver enzymes.
    • To explore the influence of alcohol consumption on liver enzymes in hypertensive patients.

    Main Methods:

    • Cross-sectional study comparing 158 hypertensive and 105 normotensive adults (aged 45-64).
    • Measurement of serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, and alkaline phosphatase.

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  • Analysis of alcohol intake in relation to liver enzyme levels.

    • Main Results:

    • Hypertensive patients exhibited significantly higher serum concentrations of ALT and AST.
    • Elevated ALT and AST levels were observed more frequently in the hypertensive group.
    • Serum bilirubin and alkaline phosphatase levels were comparable between both groups.
    • In hypertensive individuals, higher aminotransferase levels correlated with increased alcohol consumption.

    Conclusions:

    • Hypertension is associated with altered liver enzyme profiles, particularly elevated aminotransferases.
    • These findings suggest a potential link between hypertension and subclinical liver dysfunction.
    • Alcohol intake may exacerbate liver enzyme elevations in hypertensive individuals, warranting further investigation.