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Changes in peripheral and central nerve conduction with aging.

R A Mackenzie, L H Phillips

    Clinical and Experimental Neurology
    |January 1, 1981
    PubMed
    Summary
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    Aging affects nerve conduction, slowing signals from the ankle to the brain. While peripheral and thoraco-lumbar potentials decrease, central conduction time increases, particularly in upper pathways.

    Area of Science:

    • Neuroscience
    • Electrophysiology
    • Gerontology

    Background:

    • Nerve conduction studies are crucial for assessing neurological function.
    • Age-related changes in the nervous system can impact sensory and motor pathways.
    • Understanding these changes is vital for diagnosing and managing age-related neurological conditions.

    Purpose of the Study:

    • To investigate the age-related electrophysiological changes in the posterior tibial nerve pathway.
    • To assess how peripheral and central nerve conduction times are affected by aging.
    • To determine if specific segments of the central nervous system show differential age-related alterations.

    Main Methods:

    • Electrophysiological recordings were performed on 30 healthy subjects aged 20-70 years.

    Related Experiment Videos

  • Posterior tibial nerve stimulation at the ankle.
  • Simultaneous recordings were made over the thoraco-lumbar spine, cervical spine, and central sensory cortex.

    • Main Results:

    • Peripheral motor and sensory potential amplitudes significantly decreased with age.
    • Thoraco-lumbar potential amplitude also decreased significantly with age.
    • Peak latencies for thoraco-lumbar, cervical, and central potentials significantly increased with age, indicating slower conduction.

    Conclusions:

    • Nerve signal transmission slows with age, particularly in central pathways.
    • While peripheral and thoraco-lumbar nerve potentials decline, central conduction time prolongs, especially in more rostral (upper) pathways.
    • These findings highlight significant age-related alterations in the central nervous system's conduction properties.