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Related Experiment Videos

[Function of arginine in enzymes].

F Schneider

    Die Naturwissenschaften
    |July 1, 1978
    PubMed
    Summary

    Arginine, an amino acid, appears less frequently in proteins than its genetic code suggests. Its unique properties are crucial for enzyme function, particularly in binding anionic molecules.

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    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Genetics

    Context:

    • The genetic code allocates a high proportion of codons to arginine, yet its average content in proteins is surprisingly low.
    • Investigates the discrepancy between arginine's codon frequency and its actual abundance in proteomes.
    • Explores the biochemical and functional significance of arginine residues in protein structures.

    Purpose:

    • To discuss potential reasons for the underrepresentation of arginine in proteins.
    • To describe the chemical properties of arginine and methods for its modification.
    • To elucidate the role of arginine in enzyme catalysis, focusing on substrate binding.

    Summary:

    • Presents a comprehensive analysis of arginine's low frequency in proteins despite abundant codons.
    • Details the chemical characteristics of arginine, emphasizing the guanido group's influence.
    • Highlights arginine's critical role in enzyme-substrate interactions, particularly with anionic molecules.

    Impact:

    • Provides insights into the evolutionary and functional constraints shaping protein composition.
    • Enhances understanding of enzyme mechanisms and the specific roles of amino acids.
    • Offers valuable information for protein engineering and drug design targeting enzyme active sites.

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