The effect of trimipramine, cimetidine and atropine on gastric secretion

A comparison was made of increasing doses of trimipramine (0.05-0.40 mg/kg/h), atropine (7-28 microgram/kg/h) and cimetidine (0.30-2.40 mg/kg/h) on the gastric secretion stimulated by 3 microgram/kg/h of histamine dihydrochloride as continuous infusion, each dose step lasting 30 minutes. In 9 healthy subjects it was found that trimipramine had no significant effect on the output of acid. The largest dose of atropine caused a reduction by 77%, and cimetidine a reduction of 89% during the last 15 minutes portions. The study suggests that the healing of peptic ulcer by trimipramine is not linked to the effect on the histamine-stimulated gastric acid secretion.