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Plasma catecholamines in long-term diabetes.

U Cordes, J Beyer, A von Ungern-Sternberg

    Hormone and Metabolic Research. Supplement Series
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

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    Diabetic patients show impaired norepinephrine regulation after exercise, indicating potential sympathetic nerve defects. This slower recovery of plasma norepinephrine levels is linked to diabetes duration.

    Area of Science:

    • Endocrinology
    • Cardiovascular Physiology
    • Diabetic Complications

    Background:

    • Sympathetic nervous system plays a crucial role in regulating blood vessel tone.
    • Diabetic neuropathy can affect autonomic function, including sympathetic innervation.
    • Understanding these effects is vital for managing cardiovascular risks in diabetes.

    Purpose of the Study:

    • To investigate potential defects in sympathetic innervation of blood vessels in diabetic individuals.
    • To compare norepinephrine (NE) regulation in response to stress between normal and diabetic subjects.
    • To explore the relationship between diabetes duration and sympathetic response.

    Main Methods:

    • Study included 18 normal controls and 26 juvenile diabetics (13 without and 13 with complications).

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  • Subjects underwent norepinephrine infusion and a standardized exercise test (150 Watt load for 2 minutes).
  • Plasma catecholamine levels, specifically norepinephrine, were measured under these conditions.

    • Main Results:

    • Diabetic patients exhibited higher plasma norepinephrine levels during infusion compared to normals.
    • Following exercise, norepinephrine levels in normal individuals returned to baseline within 5 minutes.
    • Diabetics demonstrated a slower rate of norepinephrine fall-back post-exercise, correlated with diabetes duration.

    Conclusions:

    • Juvenile diabetics exhibit impaired norepinephrine regulation, suggesting a defect in sympathetic innervation.
    • The slower recovery of plasma norepinephrine post-exercise is associated with the duration of diabetes.
    • These findings highlight potential cardiovascular autonomic dysfunction in diabetic patients.