Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HLA B27 negative ankylosing spondylitis--a rare condition.

S R Rudge, B L Treadwell

    Australian and New Zealand Journal of Medicine
    |April 1, 1980
    PubMed
    Summary

    New criteria suggest HLA B27 negative ankylosing spondylitis is rarer than previously believed. This study examines two cases meeting these strict definitions and discusses their implications for future research.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Disease Activity Score 28-ESR bears a similar relationship to treatment decisions across different rheumatologists, but misclassification is too frequent to replace physician judgement.

    Rheumatology (Oxford, England)·2008
    Same author

    Preparation, characterization, and performance of magnetic iron-carbon composite microparticles for chemotherapy.

    Biomaterials·2000
    Same author

    Effect of carbohydrate ingestion on performance of non-fasted cyclists during a simulated 80-mile time trial.

    The Journal of sports medicine and physical fitness·1994
    Same author

    The management of rheumatoid arthritis.

    The New Zealand medical journal·1994
    Same author

    Electrokinetic isolation of vesicles and ribosomes derived from Serratia marcescens.

    Biotechnology progress·1992
    Same author

    Juvenile chronic arthritis and Wegener's granulomatosis.

    British journal of rheumatology·1992

    Area of Science:

    • Rheumatology and Immunology

    Background:

    • Ankylosing spondylitis (AS) is a chronic inflammatory disease.
    • Human Leukocyte Antigen B27 (HLA B27) is a genetic marker associated with AS.
    • The prevalence of HLA B27 negative AS requires clarification.

    Observation:

    • Two cases of ankylosing spondylitis were identified that strictly adhere to recently proposed diagnostic criteria.
    • These cases were negative for the HLA B27 genetic marker.
    • Family studies were conducted to investigate genetic and environmental factors.

    Findings:

    • The application of new, stringent criteria indicates that HLA B27 negative ankylosing spondylitis is less prevalent than previously estimated.
    • The presented cases fulfill these updated diagnostic standards for non-HLA B27 associated AS.
    • Family data provided insights into the inheritance patterns and familial aggregation.

    Implications:

    • Revised diagnostic criteria necessitate a re-evaluation of the epidemiology of HLA B27 negative ankylosing spondylitis.
    • Future research on non-HLA B27 AS should adopt these stricter criteria for accurate case ascertainment.
    • Understanding the distinct characteristics of HLA B27 negative AS may lead to targeted therapeutic strategies.

    Related Experiment Videos