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Updated: Aug 19, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
Extensive bone marrow infarction followed by myelofibrosis in patient with Ph' positive chronic granulocytic
Abstract:
A 28-year-old man with Philadelphia chromosome positive chronic granulocytic leukaemia developed extensive bone marrow and bone infarction which was associated with anaemia and thrombocytopenia. He survived 20 months from the first symptoms of bone marrow infarction; during this time he developed myelofibrosis and osteosclerosis followed by blastic transformation. Extensive bone marrow infarction is a possible pathogenetic mechanism when chronic granulocytic leukaemia is followed by myelofibrosis.
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